30. Skye McCole Bartusiak (Age 21)

Skye McCole Bartusiak won hearts as Mel Gibson’s young daughter in The Patriot (2000) and delivered strong performances in Don’t Say a Word, The Cider House Rules, and Boogeyman. She was widely regarded as one of the most talented young actresses of her generation.
Skye died at 21 from an accidental overdose involving prescription medication and alcohol. Her family established a foundation in her memory to raise awareness about substance abuse among young people. Her gentle spirit and natural talent are still remembered fondly by fans and co-stars alike.